BlackRock Health Sciences Opportunities Portfolio

S000001877BlackRock FundsCIK 0000844779

Share classes

4 classes of this one portfolio · 0 exchange-listed

Class ID	Symbol	Status	Security in the master	Type
C000004913	SHISX	NOT_LISTED	not exchange-listed	—
C000004914	SHSAX	NOT_LISTED	not exchange-listed	—
C000004916	SHSCX	NOT_LISTED	not exchange-listed	—
C000004912	SHSSX	NOT_LISTED	not exchange-listed	—

The share-class bridge is a snapshot, not history. The SEC's fund share-class file says what each class trades as today, not what it traded as at a past report date. A fund that changed ticker or converted from a mutual fund resolves to its present-day symbol for every historical month shown.

Share classes

Report period

1 period filed. Holdings below describe the selected month only.

2026-02-27

Filing

NPORT-P · filed 2026-04-24

Report date: 2026-02-27
Net assets: $6,532,498,047.69
Total assets: $6,598,804,192.45
Total liabilities: $66,306,144.76
Assets invested: $0
Cash not reported in C or D: $10,107,794.21
Amendment: No
Accession: 0000940400-26-014709

By asset category

N-PORT Item C.4.a

ECEquity - common$6.41B97.5%

STIVShort-term investment veh…$91.66M1.4%

EPEquity - preferred$70.99M1.1%

OTHEROther; the filer describe…$565.3K0.0%

By asset category

By issuer category

N-PORT Item C.4.b

CORPCorporate$6.49B98.6%

RFRegistered fund$91.66M1.4%

By issuer category

By investment country

as filed

USUS$5.88B89.7%

CHCH$147.42M2.2%

IEIE$146.89M2.2%

ILIL$117.67M1.8%

GBGB$106.63M1.6%

NLNL$93.06M1.4%

BEBE$17.47M0.3%

BMBM$13.56M0.2%

JPJP$13.27M0.2%

CACA$8.02M0.1%

JEJE$7.85M0.1%

CNCN$6.52M0.1%

By country

Classification look-through

Positions resolved to the master through ISIN, then rolled up through the taxonomy. 93.4% of reported value reaches a classification.

Equity · Health Care(123)$6.09B92.7%

Not resolved to the master(40)$435.71M6.6%

Equity · Consumer Staples(1)$28.71M0.4%

Equity · Information Technology(1)$18.09M0.3%

Classification covers part of the master. 5,771 of 13,106 active securities are classified. Anything unclassified is shown as its own band rather than dropped, so a look-through total that falls short of 100% is telling you about coverage, not about the fund.

Percentages are of the reported value of positions above ($6.58B), not of the fund’s net assets ($6.53B). The two differ by cash, derivatives filed with no market value, and rounding.

Issuer↕	In master	CUSIP / ISIN	Asset	Balance↕	Value↕	Weight▼	Country
United Therapeutics Corporation United Therapeutics Corporation COM	UTHR	91307C102 US91307C1027	EC CORP	55,689 NS	$28.06M	0.430%	US
NATERA INC Natera Inc. COM	NTRA	632307104 US6323071042	EC CORP	130,279 NS	$27.10M	0.415%	US
IQVIA Holdings Inc. IQVIA Holdings Inc. COM	IQV	46266C105 US46266C1053	EC CORP	141,190 NS	$25.25M	0.386%	US
The Cooper Companies, Inc. The Cooper Companies, Inc. COM	COO	216648501 US2166485019	EC CORP	293,135 NS	$24.53M	0.375%	US
Centene Corp. Centene Corp. COM	CNC	15135B101 US15135B1017	EC CORP	545,618 NS	$24.49M	0.375%	US
Biomarin Pharmaceutical Inc. Biomarin Pharmaceutical Inc. COM	BMRN	09061G101 US09061G1013	EC CORP	322,635 NS	$19.92M	0.305%	US
Illumina Inc Illumina Inc COM	ILMN	452327109 US4523271090	EC CORP	145,933 NS	$19.62M	0.300%	US
GE Healthcare Technologies Inc. GE Healthcare Technologies Inc. COMMON STOCK	GEHC	36266G107 US36266G1076	EC CORP	226,856 NS	$19.12M	0.293%	US
Bruker Corporation Bruker Corporation COM	BRKR	116794108 US1167941087	EC CORP	471,949 NS	$18.93M	0.290%	US
Veeva Systems Inc Veeva Systems Inc CL A COM	VEEV	922475108 US9224751084	EC CORP	99,401 NS	$18.09M	0.277%	US
Quest Diagnostics Incorporated Quest Diagnostics Incorporated COM	DGX	74834L100 US74834L1008	EC CORP	85,193 NS	$18.05M	0.276%	US
Repligen Corporation Repligen Corporation COM	RGEN	759916109 US7599161095	EC CORP	136,584 NS	$17.58M	0.269%	US
Stoke Therapeutics Inc Stoke Therapeutics Inc COM	STOK	86150R107 US86150R1077	EC CORP	473,152 NS	$17.23M	0.264%	US
Steris PLC Steris PLC ORD USD0.001	STE	000000000 IE00BFY8C754	EC CORP	64,935 NS	$16.39M	0.251%	IE
UCB SA UCB SA NPV	—	000000000 BE0003739530	EC CORP	53,577 NS	$16.09M EUR	0.246%	BE
Terns Pharmaceuticals Inc. Terns Pharmaceuticals Inc. COM	—	880881107 US8808811074	EC CORP	367,842 NS	$15.49M	0.237%	US
West Pharmaceutical Services Incorporated West Pharmaceutical Services Incorporated COM	WST	955306105 US9553061055	EC CORP	60,429 NS	$15.37M	0.235%	US
Summit Therapeutics Inc. Summit Therapeutics Inc. COM	SMMT	86627T108 US86627T1088	EC CORP	924,148 NS	$15.33M	0.235%	US
Viridian Therapeutics Inc Viridian Therapeutics Inc COM	VRDN	92790C104 US92790C1045	EC CORP	516,095 NS	$15.16M	0.232%	US
Humana Inc. Humana Inc. COM	HUM	444859102 US4448591028	EC CORP	78,693 NS	$14.99M	0.230%	US
Viking Therapeutics Inc. Viking Therapeutics Inc. COM	VKTX	92686J106 US92686J1060	EC CORP	425,324 NS	$14.39M	0.220%	US
Apogee Therapeutics Inc. Apogee Therapeutics Inc. COM	APGE	03770N101 US03770N1019	EC CORP	202,950 NS	$14.21M	0.217%	US
Ionis Pharmaceuticals, Inc. Ionis Pharmaceuticals, Inc. COM	IONS	462222100 US4622221004	EC CORP	170,008 NS	$13.80M	0.211%	US
LB Pharmaceuticals Inc. LB Pharmaceuticals Inc. COM SHS	LBRX	50180M108 US50180M1080	EC CORP	567,627 NS	$13.63M	0.209%	US
Bridgebio Pharma Inc Bridgebio Pharma Inc COM	BBIO	10806X102 US10806X1028	EC CORP	204,874 NS	$13.62M	0.208%	US
Roivant Sciences Ltd Roivant Sciences Ltd SHS	ROIV	000000000 BMG762791017	EC CORP	468,548 NS	$13.56M	0.208%	BM
Daiichi Sankyo Co Ltd. Daiichi Sankyo Co Ltd. NPV	—	000000000 JP3475350009	EC CORP	673,800 NS	$13.27M JPY	0.203%	JP
Elanco Animal Health Inc Elanco Animal Health Inc COM	ELAN	28414H103 US28414H1032	EC CORP	483,249 NS	$12.76M	0.195%	US
Cytokinetics Inc Cytokinetics Inc COM NEW	CYTK	23282W605 US23282W6057	EC CORP	184,777 NS	$11.50M	0.176%	US
Bio-Techne Corp Bio-Techne Corp COM	TECH	09073M104 US09073M1045	EC CORP	193,925 NS	$11.44M	0.175%	US
MBX Biosciences, Inc. MBX Biosciences, Inc. COM	MBX	55287L101 US55287L1017	EC CORP	333,350 NS	$10.85M	0.166%	US
Arcellx Inc Arcellx Inc COMMON STOCK	—	03940C100 US03940C1009	EC CORP	92,964 NS	$10.58M	0.162%	US
Glaukos Corp. Glaukos Corp. COM	GKOS	377322102 US3773221029	EC CORP	87,150 NS	$10.49M	0.161%	US
Hologic Inc Hologic Inc COM	—	436440101 US4364401012	EC CORP	138,368 NS	$10.43M	0.160%	US
Agios Pharmaceuticals Inc Agios Pharmaceuticals Inc COM	AGIO	00847X104 US00847X1046	EC CORP	344,876 NS	$10.43M	0.160%	US
Neurocrine Biosciences Inc Neurocrine Biosciences Inc COM	NBIX	64125C109 US64125C1099	EC CORP	78,721 NS	$10.41M	0.159%	US
Exelixis, Inc. Exelixis, Inc. COM	EXEL	30161Q104 US30161Q1040	EC CORP	231,652 NS	$10.21M	0.156%	US
ADARX PHARMACEUTICALS INC	—	000000000 —	EC CORP	769,230 NS	$10.08M	0.154%	US
Charles River Laboratories International, Inc. Charles River Laboratories International, Inc…	CRL	159864107 US1598641074	EC CORP	56,177 NS	$10.03M	0.153%	US
Scholar Rock Holding Corp. Scholar Rock Holding Corp. COM	SRRK	80706P103 US80706P1030	EC CORP	226,209 NS	$10.01M	0.153%	US
Eikon Therapeutics Inc. Eikon Therapeutics Inc. COM	EIKN	282564103 US2825641036	EC CORP	722,389 NS	$9.95M	0.152%	US
Erasca Inc Erasca Inc COM	ERAS	29479A108 US29479A1088	EC CORP	709,864 NS	$9.70M	0.148%	US
Arcus Biosciences Inc. Arcus Biosciences Inc. COM	RCUS	03969F109 US03969F1093	EC CORP	455,542 NS	$9.28M	0.142%	US
Alumis Inc Alumis Inc COM	ALMS	022307102 US0223071020	EC CORP	293,662 NS	$8.72M	0.133%	US
Maze Therapeutics Inc Maze Therapeutics Inc COM	MAZE	578784100 US5787841007	EC CORP	184,453 NS	$8.41M	0.129%	US
LARONDE INC	—	000000000 —	EC CORP	386,520 NS	$8.40M	0.129%	US
Ventyx Biosciences Inc. Ventyx Biosciences Inc. COM	—	92332V107 US92332V1070	EC CORP	590,649 NS	$8.25M	0.126%	US
Bright Minds Biosciences Inc Bright Minds Biosciences Inc COM NEW	DRUG	10919W405 CA10919W4056	EC CORP	95,655 NS	$8.02M	0.123%	CA
Novocure Ltd Novocure Ltd COM USD0.00	NVCR	000000000 JE00BYSS4X48	EC CORP	574,295 NS	$7.85M	0.120%	JE
Edgewise Therapeutics Inc. Edgewise Therapeutics Inc. COM	EWTX	28036F105 US28036F1057	EC CORP	256,164 NS	$7.80M	0.119%	US