SYRESpyre Therapeutics, Inc. Common Stock

CSNasdaq (XNAS)·USD

Identity

Security key: 22265
Ticker: SYRE
Type: CS — Common Stock
Exchange: Nasdaq(XNAS)
Venue group: NASDAQ
Operating MIC: XNAS
Market: stocks
Locale: us
Currency: USD
Listed: 2016-04-07
Round lot: 100
Active: Yes
Last seen in a load: 2026-08-14 20:49
Vendor updated: 2026-08-13 06:09
Ticker root / suffix: SYRE

Detail

Enriched 2026-08-14 20:47

Market cap: $9,178,006,886.58
Shares outstanding (class): 87,936,477
Shares outstanding (weighted): 88,173,762
SIC: 2834 PHARMACEUTICAL PREPARATIONS
Employees: 112
Location: WALTHAM, MA
Homepage: https://www.spyre.com
Description: Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting α4β7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.

Market cap and share counts drift.

Funds holding this security

122 funds · 123 positions · $659.20M reported value, as of 2026-03-31

All holders →

Fund	Ticker	Position value	% of fund	Balance	Match
SMALLCAP World Fund Inc SMALLCAP World Fund Inc	—	$121.70M	0.15%	2,412,693 NS	FIGI
VANGUARD TOTAL STOCK MARKET INDEX FUND VANGUARD INDEX FUNDS	VTI	$111.91M	0.01%	2,218,648 NS	FIGI
iShares Russell 2000 ETF iShares Trust	IWM	$85.02M	0.12%	1,685,561 NS	FIGI
State Street(R) SPDR(R) S&P(R) Biotech ETF SPDR SERIES TRUST	XBI	$53.95M	0.73%	1,069,556 NS	FIGI
T. Rowe Price Health Sciences Fund, Inc. T. ROWE PRICE HEALTH SCIENCES FUND, INC.	—	$43.08M	0.40%	854,145 NS	FIGI
VANGUARD EXTENDED MARKET INDEX FUND VANGUARD INDEX FUNDS	VXF	$38.37M	0.05%	760,693 NS	FIGI
iShares Biotechnology ETF iShares Trust	IBB	$24.16M	0.30%	478,909 NS	FIGI
iShares Russell 2000 Growth ETF iShares Trust	IWO	$19.06M	0.16%	377,778 NS	FIGI
JPMorgan Small Cap Growth Fund JPMorgan Trust II	—	$16.73M	0.77%	331,592 NS	FIGI
Driehaus Small Cap Growth Fund Driehaus Mutual Funds	—	$14.07M	1.23%	278,936 NS	FIGI
T. Rowe Price Integrated U.S. Small-Cap Growth … T. ROWE PRICE INTEGRATED EQUITY FUNDS, INC.	—	$13.80M	0.17%	273,547 NS	FIGI
iShares Russell 2000 Value ETF iShares Trust	IWN	$9.83M	0.08%	194,976 NS	FIGI
VIP Health Care Portfolio Variable Insurance Products Fund IV	—	$8.47M	0.84%	168,000 NS	FIGI
Driehaus Micro Cap Growth Fund Driehaus Mutual Funds	—	$6.85M	1.50%	135,823 NS	FIGI
Master Small Cap Index Series Quantitative Master Series LLC	—	$5.72M	0.12%	113,384 NS	FIGI

How positions resolve to the securities master. FIGI_COMPOSITE is exact identifier equality — both sides got the FIGI from Bloomberg. TICKER is a narrow fallback used only where the master row carries no FIGI at all (2,389 rows do not, disproportionately Irish-domiciled US listings like LIN and ACN). Roughly 22% of all positions resolve to the master.

Funds holding this security

Identifiers

master.security_identifier

TICKERSYRE
FIGI_COMPOSITEBBG0067L94B2
FIGI_SHARE_CLASSBBG0067L94C1
CIK0001636282
ISINUS00773J2024
Resolved through OpenFIGI from a holdings ISIN, not supplied by the securities vendor.

Identifiers

Classification

classification.v_security_classification

Asset class: Equity
Sector: Health Care
Industry: Pharmaceuticals
Source: LLMunreviewed
Self-reported confidence: 0.95
Model: deepseek
Rationale: Common stock of a pharmaceutical company, classified under healthcare and pharmaceuticals.

Classifications are unreviewed model output. All 5,771 assignments carry source = LLM and is_reviewed = false. Confidence is the model’s own estimate and is not calibrated — it clustered at 0.90–0.98 across the whole first pass, including rows that later proved wrong. Use it to order a review queue, not as a probability. Two share classes of one issuer can disagree.

Classification

Fund data

Not linked to a fund series.

Either this is not a fund, or it is one the SEC share-class snapshot cannot reach — commodity trusts and notes have no series ID at all.